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112208

Sigma-Aldrich

4-Nitrobenzoyl chloride

98%

Synonym(s):

p-Nitrobenzoyl chloride

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About This Item

Linear Formula:
O2NC6H4COCl
CAS Number:
122-04-3
Molecular Weight:
185.56
Beilstein:
473192
EC Number:
204-517-4
MDL number:
MFCD00007345
UNSPSC Code:
12352100
PubChem Substance ID:
24847076
NACRES:
NA.22

Quality Level

200

Assay

98%

form

solid

bp

202-205 °C/105 mmHg (lit.)

mp

71-74 °C (lit.)

SMILES string

[O-][N+](=O)c1ccc(cc1)C(Cl)=O

InChI

1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H

InChI key

SKDHHIUENRGTHK-UHFFFAOYSA-N

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General description

4-Nitrobenzoyl chloride reacts with triphenylphosphonium salt to synthesize benzofurans (potential positron emission tomography (PET) tracers) by the intramolecular Wittig reaction.It has been used for the derivatisation of Adiol (Androstenediol, an endogenous proliferation agent of prostate cancer).

Application

<ul>
<li><strong>Automated Synthesis of [11C]PiB:</strong> 4-Nitrobenzoyl chloride is utilized in the automated synthesis of [11C]PiB, a radiopharmaceutical for PET imaging of amyloid, highlighting its role in enhancing neuroimaging techniques (Singh et al., 2024).</li>
</ul>

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H290,H314

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

215.6 °F - closed cup

Flash Point(C)

102 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Tatsuya Higashi et al.
Steroids, 71(7), 609-617 (2006-04-20)
The liquid chromatography-mass spectrometry (LC-MS) methods were developed and validated for the determination of testosterone (T) in the brain and serum of rats and of 5alpha-androstane-3alpha,17beta-diol (ADIOL), a metabolite of T, in the brain of rats. After derivatization of T
[Experimental establishment of the maximum permissible concentration of para-nitrobenzoylchloride in the air of a work area].
M Ia Kudria et al.
Gigiena truda i professional'nye zabolevaniia, (9)(9), 47-48 (1984-09-01)
Masahiro Ono et al.
Journal of medicinal chemistry, 49(9), 2725-2730 (2006-04-28)
A novel series of benzofuran derivatives as potential positron emission tomography (PET) tracers targeting amyloid plaques in Alzheimer's disease (AD) were synthesized and evaluated. The syntheses of benzofurans were successfully achieved by an intramolecular Wittig reaction between triphenylphosphonium salt and
Tatsuya Higashi et al.
Steroids, 71(11-12), 1007-1013 (2006-09-19)
Androstenediol (Adiol, androst-5-ene-3beta,17beta-diol) is suspected of being an endogenous proliferation agent of prostate cancer (PCa) even after androgen deprivation therapy (ADT). A liquid chromatography-electron capture atmospheric pressure chemical ionization-mass spectrometric (LC-ECAPCI-MS) method for the determination of Adiol in prostatic tissue
M Ishigai et al.
Analytical biochemistry, 298(1), 83-92 (2001-10-25)
The dynamics of enzyme-catalyzed glutathione conjugation was studied by electrospray quadrupole/time-of-flight (Q-TOF) mass spectrometry with a nanospray interface. After incubation of human glutathione S-transferase A1-1 (GT) with glutathione (GSH) and an electrophilic substrate, electrospray indicated the presence of enzyme/product adducts
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