SML0806

7DG

≥95% (HPLC)

• Sinônimo(s): 7-Desacetoxy-6,7-dehydrogedunin
• Fórmula empírica (Notação de Hill): C₂₆H₃₀O₅
• Número CAS: 26927-01-5
• Peso molecular: 422.51
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

Propriedades

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• shipped in: wet ice
• storage temp.: 2-8°C

Descrição

General description

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.

Biochem/physiol Actions

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR).

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC₅₀) of 5 μM, showing a role for PKR in pyroptosis.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de armazenamento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable