PZ0162

PD 0325901

≥98% (HPLC)

• Sinônimo(s): N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
• Fórmula empírica (Notação de Hill): C₁₆H₁₄F₃IN₂O₄
• Número CAS: 391210-10-9
• Peso molecular: 482.19
• Número MDL: MFCD08435926
• Código UNSPSC: 12352200
• ID de substância PubChem: 329823743

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
• cor: white to off-white
• solubilidade: DMSO: 20 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F
• InChI: 1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
• chave InChI: SUDAHWBOROXANE-SECBINFHSA-N
• Informações sobre genes: human ... MAP2K1(5604) , MAP2K2(5605)

Descrição

Aplicação

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Ações bioquímicas/fisiológicas

PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma and melanoma tumor progression.

PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Características e benefícios

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H373,H413
• Declarações de precaução: P260 - P264 - P273 - P301 + P310 - P314 - P405
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable