E7906

Esomeprazole magnesium hydrate

≥98% (HPLC), proton pump inhibitor, powder

• Sinônimo(s): (S)-Omeprazole magnesium hydrate, (T-4)-Bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-Magnesium hydrate, Nexium hydrate
• Fórmula empírica (Notação de Hill): C₃₄H₃₆MgN₆O₆S₂ · xH₂O
• Número CAS: 668985-31-7
• Peso molecular: 713.12 (anhydrous basis)
• MDL number: MFCD11226784
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799074
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propriedades

• Nome do produto: Esomeprazole magnesium hydrate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -128 to -146°, c = 0.5 in methanol
• color: white to off-white
• solubility: DMSO: ≥5 mg/mL
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: O.COc1ccc2n([Mg]n3c(nc4cc(OC)ccc34)S(=O)Cc5ncc(C)c(OC)c5C)c(nc2c1)S(=O)Cc6ncc(C)c(OC)c6C
• InChI: 1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;/t2*24-;;/m00../s1
• InChI key: LGRFYKXKCZKDLS-DIYDTZFBSA-N

Descrição

General description

Esomeprazole is the (S)-isomer of omeprazole. It blocks the H⁺/K⁺-ATPase enzyme and lowers the release of hydrochloric acid by gastric parietal cells. Esomeprazole is used for treating gastroesophageal reflux disease (GERD).

Application

Esomeprazole magnesium hydrate has been used to induce intracellular acidification in an ATP12A-independent manner.

Biochem/physiol Actions

Esomeprazole magnesium dihydrate is a leading proton pump inhibitor.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra de aviso: Warning
• Códigos de risco: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de armazenamento: 11 - Combustible Solids
• O que está acontecendo?: WGK 3
• Ponto de inflamação (°F): Not applicable
• Ponto de inflamação (°C): Not applicable
• EPI (equipamento de proteção individual): Eyeshields, Gloves, type N95 (US)