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C8138

Chlorpromazine hydrochloride

≥98% (TLC), powder, D2 dopamine receptor antagonist

Sinônimo(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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Sobre este item

Fórmula empírica (Notação de Hill):
C17H19ClN2S · HCl
Número CAS:
69-09-0
Peso molecular:
355.33
NACRES:
NA.77
PubChem Substance ID:
57654045
UNSPSC Code:
12352200
EC Number:
200-701-3
MDL number:
MFCD00012654
Beilstein/REAXYS Number:
3779989
Assay:
≥98% (TLC)
Form:
powder
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Nome do produto

Chlorpromazine hydrochloride, ≥98% (TLC)

Quality Segment

200

assay

≥98% (TLC)

form

powder

mp

194-196 °C

solubility

water: 50 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR2A(3356)

Application

Chlorpromazine hydrochloride has been used:
  • as an antagonists for calmodulin kinase[1]
  • as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
  • as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number

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Questions

  1. Dear, I bought your product C8138 Chlorpromazine. I have few practical questions: - Can it be dissolved in DMSO? - Can it be dissolved in Phosphate-buffered saline? - What is the storage temperature of the dissolved product?

    1 answer

    1. This product is tested for solubility in water at 50 mg/mL. Other published sources state that this compound is also soluble in organic solvents such as DMSO and alcohols. Solution stability studies have not been perofrmed, however the Chlorpromazine HCl analytical standard, product C-904, is a 1 mg/mL solution in methanol. This item is not assigned an expiration date and is considered stable for at least 1 year from the date of shipment when stored at ?20°C.

      Please see the link below to review the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/966/223/c8138pis.pdf

      Please see the link below to review a publication related to the stability of this compound in water:
      http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705283/pdf

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