692000

ZM 336372

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM).

• Sinônimo(s): ZM 336372, N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
• Fórmula empírica (Notação de Hill): C₂₃H₂₃N₃O₃
• Número CAS: 208260-29-1
• Peso molecular: 389.45
• Número MDL: MFCD02683971
• Código UNSPSC: 12352117
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: DMSO: 200 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O
• InChI: 1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
• chave InChI: PYEFPDQFAZNXLI-UHFFFAOYSA-N

Descrição

Descrição geral

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM).

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Protein kinase c-Raf

Product competes with ATP.

Reversible: yes

Target IC₅₀: 70 nM against protein kinase c-Raf

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Outras notas

Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.

Informações legais

Sold under license of PCT Application W098/22,103.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317,H413
• Declarações de precaução: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Classificações de perigo: Aquatic Chronic 4 - Skin Sens. 1B
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable