342000

Caspase Inhibitor, Negative Control

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinônimo(s): Caspase Inhibitor, Negative Control, Z-FA-FMK, Cathepsin B, Inhibitor I
• Fórmula empírica (Notação de Hill): C₂₁H₂₃FN₂O₄
• Número CAS: 105637-38-5
• Peso molecular: 386.42
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated
• cor: off-white
• solubilidade: DMSO: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)
• chave InChI: ASXVEBPEZMSPHB-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.

A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Cathepsin-B

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Standard Handling (A)

Sequência

Z-Phe-Ala-FMK

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Schotte, P., et al. 2001. J. Biol. Chem.276, 21153.
Guo, H., et al. 1998. Exp. Cell Res.245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest.91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol.44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable