SML3530
DMA-135
≥98% (HPLC)
Synonym(s):
3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-2-pyrazinecarboxamide hydrochloride
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C16H17N7O · xHCl
CAS Number:
Molecular Weight:
323.35 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN(C1=C(N=C(C(N)=N1)C(NC(N)=N)=O)C#CC2=CC=CC=C2)C.[xHCl]
Biochem/physiol Actions
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Also, previous data indicate that DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR
MedChemComm, 8(5), 1022-1036 (2017)
IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Nature Communications, 11(1), 4775-4775 (2020)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service