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SML3079

Sigma-Aldrich

Ponalrestat

≥98% (HPLC)

Synonym(s):

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid, ICI 128436, MK538

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5 MG
R$733.00
25 MG
R$2,966.00

R$733.00

Estimated to ship onApril 16, 2025

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5 MG
R$733.00
25 MG
R$2,966.00

About This Item

Empirical Formula (Hill Notation):
C17H12BrFN2O3
CAS Number:
72702-95-5
Molecular Weight:
391.19
MDL number:
MFCD00204117
UNSPSC Code:
12352200
NACRES:
NA.77

R$733.00

Estimated to ship onApril 16, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(CC(C1=CC=CC=C1C2=O)=NN2CC3=CC=C(C=C3F)Br)=O

InChI

1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)

InChI key

LKBFFDOJUKLQNY-UHFFFAOYSA-N

Biochem/physiol Actions

Ponalrestat is an orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2) that blocks the conversion of glucose to sorbitol. Ponalrestat promotes root elongation through the inhibition of the flavin monooxygenase YUCCA in Arabidopsis.
orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000127771
0000127770
0000127771
0000127770
0000125680

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Ajmer Singh Grewal et al.
Mini reviews in medicinal chemistry, 16(2), 120-162 (2015-09-10)
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose reductase (AR) is an enzyme of aldoketo reductase super-family
Guang Wang et al.
Chemical research in toxicology, 33(8), 2164-2171 (2020-07-09)
Bile acids (BAs) play essential physiological roles not only by facilitating the absorption and transport of nutrients but also by acting as a complex molecular signaling system. Reduced levels of BAs have been observed in obesity and other metabolic disorders.
Ying Zhu et al.
The Journal of biological chemistry, 294(52), 19923-19933 (2019-11-17)
Plant development is regulated by both synergistic and antagonistic interactions of different phytohormones, including a complex crosstalk between ethylene and auxin. For instance, auxin and ethylene synergistically control primary root elongation and root hair formation. However, a lack of chemical

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