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SML2397

Sigma-Aldrich

Dooku1

≥98% (HPLC)

Synonym(s):

2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

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5 MG
R$666.00
25 MG
R$2,696.00

R$666.00

Estimated to ship onApril 13, 2025

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All Photos(1)

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5 MG
R$666.00
25 MG
R$2,696.00

About This Item

Empirical Formula (Hill Notation):
C13H9Cl2N3OS
CAS Number:
2253744-54-4
Molecular Weight:
326.20
UNSPSC Code:
12352200
NACRES:
NA.77

R$666.00

Estimated to ship onApril 13, 2025

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2

InChI

1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2

InChI key

MNPOBXLPCWFONX-UHFFFAOYSA-N

Biochem/physiol Actions

Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.
potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000341826
0000341826
0000218343
0000218342
0000271373

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Yangmengfan Chen et al.
Journal of functional biomaterials, 14(3) (2023-03-29)
Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is supposed to simulate local EMF generated during mechanical stimulation of bone and may therefore be used to improve bone regeneration. This study aimed at optimizing the exposure strategy and investigating
Elizabeth L Evans et al.
British journal of pharmacology, 175(10), 1744-1759 (2018-03-03)
The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small-molecule agonist, but the pharmacology of these channels is otherwise limited. Yoda1 analogues were generated by synthetic chemistry. Intracellular Ca2+ and Tl+ measurements were made
Florian Labarrade et al.
International journal of cosmetic science, 45(5), 604-611 (2023-05-12)
Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from

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