SML1729
SW044248
≥98% (HPLC)
Synonym(s):
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C22H23N5O2S
CAS Number:
Molecular Weight:
421.52
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CCC(C(NC1=C(OC)C=CC=C1)=O)SC2=NC(N(CC)C3=C4C=CC=C3)=C4N=N2
Biochem/physiol Actions
SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. Nos. 208925 & C9911). SW044248 is shown to exhibit antiproliferation efficacy against a subset of non-small-cell lung cancer (NSCLC) cultures (IC50 <5 μM), including HCC4017 (IC50 = 1.68 μM) as a result of DNA damage and apoptosis induction, while exhibiting little potency toward the non-cancerous HBEC30KT lung epithelial cells (IC50 >10 μM) derived from the same patient as HCC4017.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service