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SML1346

Sigma-Aldrich

BRD32048

≥98% (HPLC)

Synonym(s):

BRD 32048, N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine

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5 MG
R$630.00
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5 MG
R$630.00
25 MG
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About This Item

Empirical Formula (Hill Notation):
C16H22N6O
CAS Number:
433694-46-3
Molecular Weight:
314.39
MDL number:
MFCD03190440
UNSPSC Code:
12352200
PubChem Substance ID:
329825802
NACRES:
NA.77

R$630.00

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC(NC2=CC=C(OC)C=C2)=NC(CN3CCCCC3)=N1

InChI

1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21)

InChI key

PVHJDJWPRZUURH-UHFFFAOYSA-N

Biochem/physiol Actions

BRD32048 is a derivative of [1,3,5]triazine. It is found in orally active phosphodiesterase inhibitors (PDE) inhibitors, DHFR (dihydrofolate reductase) inhibitors and phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors. BRD32048 binds ETS variant 1 (ETV1) and controls transcriptional activity, facilitated by ETV1 and invasion of ETV1-driven cancer cells.[1]
BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein.
BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000297935
0000297935
0000145417
065M4720V

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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Pop MS, et al.
Molecular Cancer Therapeutics, molcanther-molcan0689 (2014)

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