SML1236

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC)

• Synonym(s): (−)-Nicotine ditartrate, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂ · 2C₄H₆O₆
• CAS Number: 65-31-6
• Molecular Weight: 462.41
• EC Number: 200-607-2
• UNSPSC Code: 12352210
• PubChem Substance ID: 329825736
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +20 to +26°, c = 1.0 in water
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: CN1CCC[C@H]1C2=CC=CN=C2.C
• InChI: 1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1
• InChI key: RYYKFQGHMYGLEL-PPHPATTJSA-N

Description

Application

(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).

(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.

Biochem/physiol Actions

NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H319,H330,H361d,H411
• Precautionary Statements: P202 - P260 - P264 - P273 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point(F): 289.8 °F
• Flash Point(C): 143.2 °C