SML1215
Cuspin-1
≥98% (HPLC)
Synonym(s):
(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
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About This Item
Empirical Formula (Hill Notation):
C13H10BrNO
CAS Number:
Molecular Weight:
276.13
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
SMILES string
CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
InChI
1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
InChI key
AJZRSLVRFSCCIL-UHFFFAOYSA-N
Biochem/physiol Actions
Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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