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SML0463

Sigma-Aldrich

BPD

≥98% (HPLC)

Synonym(s):

3-(1,3-benzodioxol-5-yl)-4-phenyl-2,5-Furandione

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About This Item

Empirical Formula (Hill Notation):
C17H10O5
CAS Number:
213481-12-0
Molecular Weight:
294.26
MDL number:
MFCD22666591
UNSPSC Code:
12352200
PubChem Substance ID:
329824741

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

O=C1OC(=O)C(c2ccc3OCOc3c2)=C1c4ccccc4

InChI

1S/C17H10O5/c18-16-14(10-4-2-1-3-5-10)15(17(19)22-16)11-6-7-12-13(8-11)21-9-20-12/h1-8H,9H2

InChI key

IMHGOAWBSJVILI-UHFFFAOYSA-N

Biochem/physiol Actions

BPD inhibits LPS-induced NF-kB signaling by inactivation of TAK-1. BPD is also known to inhibit the expression and activity of COX-2.

Features and Benefits

This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H400

Precautionary Statements

P273

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sebastian Euler et al.
Frontiers in psychology, 9, 824-824 (2018-06-19)
Interpersonal sensitivity, particularly threat of potential exclusion, is a critical condition in borderline personality disorder (BPD) which impairs patients' social adjustment. Current evidence-based treatments include group components, such as mentalization-based group therapy (MBT-G), in order to improve interpersonal functioning. These
Jennifer Sophie Landry et al.
Annals of the American Thoracic Society, 13(1), 17-24 (2015-11-03)
Bronchopulmonary dysplasia and the long-term consequences of prematurity are underrecognized entities, unfamiliar to adult clinicians. Well described by the pediatric community, these young adults are joining the ranks of a growing population of adults with chronic lung disease. To describe
Anna Karin Edstedt Bonamy et al.
Archives of disease in childhood. Fetal and neonatal edition, 104(1), F36-F45 (2018-01-22)
To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Area-based cohort study of all births before 32 weeks
Johanna Köhling et al.
Journal of personality disorders, 30(6), 776-795 (2015-12-02)
The quality of depression in borderline personality disorder (BPD) was reported to differ from that in patients with major depressive disorder (MDD) only. However, little is known about affect dynamics in "borderline-depression." The authors assessed affective instability and reactivity in
Carla Sharp et al.
Assessment, 26(6), 1014-1029 (2018-07-14)
DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) Section II criteria for borderline personality disorder (BPD) lack developmental operationalization. The aim of the current study was to evaluate whether DSM criteria operate similarly across adolescents and adults to
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