SCP0095
Caspase Inhibitor
≥95% (HPLC)
Synonym(s):
Ac-LEHD-CHO, caspase 9 inhibitor
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C23H34N6O9
Molecular Weight:
538.55
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Gene Information
human ... CASP9(842)
Amino Acid Sequence
Ac-Leu-Glu-His-Asp-al
Biochem/physiol Actions
Ac-Leu-Glu-His-Asp-al, or Ac-LEHD-CHO, is a cell-permeable tetrapeptide aldehyde. It is an inhibitor of caspase-9. Its target of action has been proposed to be the mitochondrial pathway of apoptosis. Ac-LEHD-CHO has also been postulated to prevent cleavage of caspase-8, and partly to prevent cleavage of caspase-3.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
PP2A mediates apoptosis or autophagic cell death in multiple
myeloma cell lines
myeloma cell lines
Hang Zhou
Oncotarget (2017)
Daniel Purich
The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads (2017)
Miyuki Tauchi et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Atherosclerotic lesions preferentially develop at bifurcations, characterized by non-uniform shear stress (SS). The aim of this study was to investigate SS-induced endothelial activation, focusing on stress-regulated mitogen-activated protein kinases (MAPK) and downstream signaling, and its relation to gap junction proteins
Hang Zhou et al.
Oncotarget, 8(46), 80770-80789 (2017-11-09)
The crosstalk between apoptosis and autophagy contributes to tumorigenesis and cancer therapy. The process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates apoptosis and autophagy as a cancer therapy is unclear. In this study, we show for the
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service