Cortactin is an actin-related protein 2/3 (Arp2/3) complex–activating and filamentous (F)-actin–binding protein. This protein is coded by CTTN gene that maps to human chromosome 11q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421.
Immunogen Range: 388-437
Application
Anti-phospho-Cortactin (pTyr421) antibody has been used in western blotting and immunoprecipitation.
Biochem/physiol Actions
Cortactin controls Arp2/3-mediated actin polymerization. This protein also modulates aggressive cancer cell traits like tumor growth, cancer cell invasion and motility, and serum- and anchorage-independent growth.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously
Cortactin contributes to the tumorigenicity of colorectal cancer by promoting cell proliferation.
Wu H, et al.
Oncology Reports, 36(6), 3497-3503 (2016)
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Sinha S, et al.
The Journal of Cell Biology, 214(2), 197-213 (2016)
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