Keratin 8 (KRT8) is an intermediate filament protein, that is located on human chromosome 12q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Keratin 8.
Immunogen Range: 41-90
Biochem/physiol Actions
Keratins act as cytoprotective proteins. KRT8 plays an important role in the pathophysiology of RPE (retinal pigment epithelium). It plays a hepatoprotective role against mechanical and toxic injury.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Keratin 8 Y54H and G62C mutations are not associated with liver disease
Halangk J, et al.
Journal of medical Genetics (2004)
Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells
Mori K, et al.
Oncology Reports, 18(6), 1365-1371 (2007)
Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation
Guldiken N, et al.
Hepatology, 62(3), 876-886 (2015)
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