The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human MYLIP.
Immunogen Range: 161-210
Application
Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(7), 1154-1166 (2017-03-25)
The kidney plays a central role in elimination of metabolic waste products and regulation of low-molecular weight metabolites via glomerular filtration, tubular secretion and reabsorption. Disruption of these processes results in profound changes in the biochemical milieu of the body
Mylip makes an Idol turn into regulation of LDL receptor
Lindholm D, et al.
Cellular and Molecular Life Sciences, 66(21), 3399-3402 (2009)
Short-term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice
Yu Q, et al.
Molecular Medicine Reports, 18(3), 2780-2788 (2018)
The link between phenotype and fatty acid metabolism in advanced chronic kidney disease
Chen DQ, et al.
Lipids in Health and Disease, 32(7), 1154-1166 (2017)
Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations
Yan TT, et al,
Lipids in Health and Disease, 11(1), 141-141 (2012)
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