Meis homeobox 1 (MEIS1) is a transcription factor. It is expressed in hematopoietic stem cells, progenitor cells and mature megakaryocytes. The protein possesses protein binding domains, a homeobox DNA binding domain and C-terminal transcriptional activation domains. The gene encoding MEIS1 is localized on human chromosome 2p15.
Immunogen
Peptide with sequence C-SEDITRSANLTDQ from the internal region of the protein sequence according to NP_002389.1.
Biochem/physiol Actions
Meis homeobox 1 (MEIS1) has a role in regular development as well as in cancer development. In mouse models, the protein has a role in renewal of stem cells. MEIS1 has been associated with acute myeloid leukemia.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
MEIS1 regulates early erythroid and megakaryocytic cell fate.
Zeddies S
Haematologica (2014)
Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma.
Rad A
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2016)
Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.
Liu J
Annals of Hematology (2017)
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