The immunogen for anti-TRIM36 antibody: synthetic peptide derected towards the N terminal of human TRIM36
Biochem/physiol Actions
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Trim36 is involved in chromosome segregation and cell cycle regulation. It may play a role in the acrosome reaction and fertilization.
Sequence
Synthetic peptide located within the following region: ESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEH
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Hormone therapy drugs, such as bicalutamide and enzalutamide, directed against prostate cancer focus on androgen receptor (AR) signaling and are initially effective, but the disease progresses to lethality as resistance to these drugs develops. A method to prolong the drug
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