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S6445

Sigma-Aldrich

S-2E

≥98% (HPLC), powder

Synonym(s):

(S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid

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About This Item

Empirical Formula (Hill Notation):
C22H25NO4
CAS Number:
Molecular Weight:
367.44
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 11 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

CC(C)(C)c1ccc(cc1)N2C[C@@H](COc3ccc(cc3)C(O)=O)CC2=O

InChI

1S/C22H25NO4/c1-22(2,3)17-6-8-18(9-7-17)23-13-15(12-20(23)24)14-27-19-10-4-16(5-11-19)21(25)26/h4-11,15H,12-14H2,1-3H3,(H,25,26)/t15-/m0/s1

InChI key

YZADMDZNVOBYGR-HNNXBMFYSA-N

Application

S-2E may be used in cell signaling studies.

Biochem/physiol Actions

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor.
HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

Packaging

Shipped ambient under nitrogen.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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