S150
Spermine–Nitric oxide complex
source of nitric oxide
Synonym(s):
N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine, SPER/NO, Spermine NONOate
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About This Item
Empirical Formula (Hill Notation):
C10H26N6O2
CAS Number:
Molecular Weight:
262.35
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
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Quality Level
form
powder
storage condition
desiccated
color
white
solubility
methanol: ≥1 mg/mL
H2O: ≥2 mg/mL
εmax
8500 at 252 nm
shipped in
dry ice
storage temp.
−20°C
SMILES string
NCCCN(N(N=O)O)CCCCNCCCN
InChI
1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2
InChI key
QPIOUFBAROSIAN-UHFFFAOYSA-N
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Application
Used to produce a controlled release of nitric oxide in solution.
Other Notes
air sensitive
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Fang Cheng et al.
Cancer letters, 273(1), 148-154 (2008-09-12)
Here we demonstrate a synergistic and tumor selective cytotoxic effect by combined treatment with naphthoxylosides, polyamine synthesis inhibitor, and polyamine based nitric oxide (NO) donor, using in vitro human tumor models. We have earlier reported that heparan sulfate priming naphthoxyloside
Travis J Bourret et al.
Scientific reports, 7(1), 15083-15083 (2017-11-10)
The PhoPQ two-component regulatory system coordinates the response of Salmonella enterica serovar Typhimurium to diverse environmental challenges encountered during infection of hosts, including changes in Mg
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained
Nadia Sachewsky et al.
Stem cells and development, 23(20), 2469-2481 (2014-05-29)
Temporally distinct populations of neural stem cells (NSCs; embryonic and adult) display the cardinal stem cell properties of self-renewal and multipotentiality; however, their relative frequency and cell kinetics vary through development and into old age. We asked whether changes in
Thais de Castro Barbosa et al.
Metabolism: clinical and experimental, 62(1), 79-89 (2012-08-15)
The amino acid Arginine (Arg) is the main biological precursor of nitric oxide (NO) and has been described to improve insulin sensitivity in diabetes and obesity. We investigated the molecular mechanisms involved in the long-term effects of Arg on glucose
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