All Photos(1)

Documents

R6775

Anti-Retinoblastoma antibody produced in rabbit

Name: Anti-Retinoblastoma antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Rb

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

MDL number:

MFCD00282455

UNSPSC Code:

12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 105 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using human colon adenocarcinoma tissue
microarray: suitable
western blot: 1:100 using human acute lymphoma Jurkat cell lysate

UniProt accession no.

P06400

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... RB1(5925)

Specificity

This sequence recognized by the antibody is highly conserved across species (e.g., mouse, rat p105 Rb) and is not found in p107 Rb and p130 Rb.

Immunogen

synthetic peptide corresponding to amino acids 914-928 of the C-terminal region of human p105 retinoblastoma protein (p105 Rb) with N-terminally added cysteine, conjugated to maleimide-activated KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?

Try our Product Selector Tool.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.

Luigi Cicatiello et al.

Molecular and cellular biology, 24(16), 7260-7274 (2004-07-30)

Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G(1)-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for normal development and physiology of the

Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10.

Dennis Ma et al.

Mitochondrion, 17, 106-115 (2014-07-19)

A water-soluble formulation of CoQ10 (WS-CoQ10) was shown to stabilize mitochondria and prevent oxidative stress-induced neuronal death. Presenilin-1 (PS-1)-mutated Alzheimer's Disease (AD) fibroblasts (PSAF) were used for studying the effects of PS-1 mutation. PS-1 mutation correlated to increased reactive oxygen

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service