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P4670

Sigma-Aldrich

Propafenone hydrochloride

Synonym(s):

1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

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5 G
R$1,291.00

R$1,291.00

Estimated to ship onMarch 29, 2025

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5 G
R$1,291.00

About This Item

Empirical Formula (Hill Notation):
C21H27NO3 · HCl
CAS Number:
34183-22-7
Molecular Weight:
377.90
EC Number:
251-867-9
MDL number:
MFCD00079243
UNSPSC Code:
41116107
PubChem Substance ID:
24278636
NACRES:
NA.77

R$1,291.00

Estimated to ship onMarch 29, 2025

form

powder

Quality Level

100

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2

InChI

1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H

InChI key

XWIHRGFIPXWGEF-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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General description

Propafenone hydrochloride is a calcium antagonist.[1] It functions as a Na+ and K+ channel blocker.[2] It might be used to treat patients with systemic hypertension.[3] Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver.[4] Propafenone hydrochloride is used to treat ventricular arrhythmias.[2]

Application

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.[5]

Biochem/physiol Actions

Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS0910
MKCN8139
MKCJ9681
MKCD0594
MKBW3969V

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The multiple modes of action of propafenone
Dukes ID and Williams EMV
European Heart Journal, 5(2), 115-125 (1984)
Propafenone hepatotoxicity: report of a new case and review of the literature
Younan LB, et al.
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 19(5), 235-235 (2013)
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes
Christe G, et al.
European Journal of Pharmacology, 373(2-3), 223-232 (1999)
Pharmacologic management of arrhythmias
Ganjehei L, et al.
Texas Heart Institute Journal, 38(4), 344-344 (2011)
Lori D Bash et al.
Cardiovascular drugs and therapy, 26(2), 167-179 (2012-03-16)
Rate and rhythm control are two well established treatment objectives for atrial fibrillation (AF) patients. While symptom reduction is a primary treatment goal, therapeutic practice related to cardioversion varies by region and patient, with several precautions associated with the use
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