Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the Ito channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.
Immunogen
synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel Kv4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).
Application
Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.
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