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I1759

Sigma-Aldrich

Isosorbide dinitrate

powder

Synonym(s):

ISDN

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About This Item

Empirical Formula (Hill Notation):
C6H8N2O8
CAS Number:
87-33-2
Molecular Weight:
236.14
MDL number:
MFCD00868238
UNSPSC Code:
12352200
PubChem Substance ID:
24895946

form

powder

contains

~60% lactose

color

white

solubility

organic solvents: soluble (alcohol, acetone and ether)

SMILES string

[H][C@@]1([C@@]([H])(O[N+]([O-])=O)CO2)[C@@]2([H])[C@]([H])(O[N+]([O-])=O)CO1

InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

InChI key

MOYKHGMNXAOIAT-UHFFFAOYSA-N

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Biochem/physiol Actions

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H207,H302

Hazard Classifications

Acute Tox. 4 Oral - Desen. Expl. 3

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this
Benjamin Medalion et al.
The Journal of thoracic and cardiovascular surgery, 150(3), 607-612 (2015-07-21)
Bilateral internal thoracic artery grafting in elderly patients is controversial. We compared the outcome of bilateral internal thoracic artery grafting with that of single internal thoracic artery and saphenous vein and radial artery conduits in these patients. Patients aged 70 years
C Sciorati et al.
British journal of pharmacology, 122(4), 687-697 (1998-01-10)
1. The role of nitric oxide (NO) in the control of cell growth is controversial since both stimulation and (more often) inhibition have been demonstrated in various cell types. In order to reinvestigate the problem and identify the sites of
S Silber
European journal of clinical pharmacology, 38 Suppl 1, S35-S51 (1990-01-01)
Nitrates are highly effective both in terminating acute attacks of angina pectoris and in the prophylaxis of symptomatic and asymptomatic myocardial ischemia. Preload reduction by venodilatation is the prevailing mechanism of nitrates in patients with chronic stable angina and is
Maria Grazia D'Angelo et al.
Pharmacological research, 65(4), 472-479 (2012-02-07)
This open-label, single centre pilot study was designed to evaluate safety and tolerability of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a non steroid anti-inflammatory drug, in a cohort of adult dystrophic patients (Duchenne
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