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I0144

Sigma-Aldrich

Indolicidin

≥97% (HPLC)

Synonym(s):

Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2

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About This Item

Empirical Formula (Hill Notation):
C100H132N26O13
CAS Number:
140896-21-5
Molecular Weight:
1906.28
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N6CCC[C@H]6C(=O)N[C@@H](Cc7c[nH]c8ccccc78)C(=O)N[C@@H](Cc9c[nH]c%10ccccc9%10)C(=O)N%11CCC[C@H]%11C(=O)N[C@@H](Cc%12c[nH]c%13ccccc%12%13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits potent antimicrobial activity in vitro against bacteria and fungi.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
100M1483
050M1430
127K1383
126K1324
124K1116

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John Oreopoulos et al.
Journal of structural biology, 168(1), 21-36 (2009-03-10)
Understanding the mechanisms of peptide-induced membrane disorder is critical to the design of novel antimicrobial and cell-penetrating peptides. One means of quantifying local structure and order/disorder is through the orientational order parameter, typically obtained using various spectroscopic approaches. We report
Setsuko Ando et al.
Journal of peptide science : an official publication of the European Peptide Society, 16(4), 171-177 (2010-03-03)
A series of Trp and Arg analogs of antibacterial indolicidin (Ind) was synthesized and the antimicrobial and hemolytic activities were investigated. [L(9)]Ind, [L(11)]Ind, [K(8),L(9)]Ind and [K(6, 8),L(9)]Ind showed desirable characteristics, exhibiting negligible hemolytic activity while keeping strong antibacterial activity. The
Tatyana I Rokitskaya et al.
Biochimica et biophysica acta, 1808(1), 91-97 (2010-09-21)
Indolicidin, a 13-residue cationic peptide with extremely high tryptophan content, exhibits broad-spectrum antimicrobial as well as hemolytic activity. To gain insight into the mechanism of indolicidin action on membrane permeability, liposome leakage induced by this peptide was studied by using
A Pompilio et al.
Peptides, 32(9), 1807-1814 (2011-08-19)
Six different cathelicidin-derived peptides were compared to tobramycin for antibacterial and anti-biofilm effects against S. aureus, P. aeruginosa, and S. maltophilia strains isolated from cystic fibrosis patients. Overall, SMAP-29, BMAP-28, and BMAP-27 showed relevant antibacterial activity (MIC(50) 4-8μg/ml), and in
M E Selsted et al.
The Journal of biological chemistry, 267(7), 4292-4295 (1992-03-05)
A potent and structurally novel antimicrobial peptide was purified from the cytoplasmic granules of bovine neutrophils. Suspensions of Staphylococcus aureus and Escherichia coli were virtually sterilized by the peptide at a concentration of 10 micrograms/ml. The peptide was found to
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