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EMU030721

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Ttr

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20 μG
R$1,765.00
50 μG
R$3,150.00

R$1,765.00


Estimated to ship onApril 15, 2025



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20 μG
R$1,765.00
50 μG
R$3,150.00

About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

R$1,765.00


Estimated to ship onApril 15, 2025


description

Powered by Eupheria Biotech

Quality Level

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TTTCACAGCCAACGACTCTGGCCATCGCCACTACACCATCGCAGCCCTGCTCAGCCCATACTCCTACAGCACCACGGCTGTCGTCAGCAACCCCCAGAATTGAGAGACTCAGCCCAGGAGGACCAGGATCTTGCCAAAGCAGTAGCATCCCATTTGTACCAAAACAGTGTTCTTGCTCTATAAACCGTGTTAGCAGCTCAGGAAGATGCCGTGAAGCATTCTTATTAAACCACCTGCTATTTCATTCAAACTGTGTTTCTTTTTTATTTCCTCATTTTTCTCCCCTGCTCCTAAAACCCAAAATTTTTTAAAGAATTCTAGAAGGTATGCGATCAAACTTTTTAAAGAAAGAAAATACTTTTTGACTCATGGTTTAAAGGCATCCTTTCCATCTTGGGGAGGTCATGGGTGCTCCTGGCAACTTGCTTGAGGAAGATAGGTCAGAAAGCAGAGTGGACCAACCGTTCAAT

Ensembl | mouse accession no.

NCBI accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Nádia P Gonçalves et al.
Acta neuropathologica communications, 2, 177-177 (2014-12-19)
Transthyretin V30M mutation is the most common variant leading to Familial Amyloidotic Polyneuropathy. In this genetic disorder, Transthyretin accumulates preferentially in the extracellular matrix of peripheral and autonomic nervous systems leading to cell death and dysfunction. Thus, knowledge regarding important
Ole B Suhr et al.
Orphanet journal of rare diseases, 10, 109-109 (2015-09-05)
Transthyretin-mediated amyloidosis is an inherited, progressively debilitating disease caused by mutations in the transthyretin gene. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of patisiran (ALN-TTR02), a small interfering RNA encapsulated within lipid nanoparticles, in patients

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