Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Synonym(s):
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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25 MG
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25 MG
R$2,081.00
100 MG
R$6,391.00
About This Item
Empirical Formula (Hill Notation):
C37H49N7O9S
CAS Number:
Molecular Weight:
767.89
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Pentagastrin, ≥95% (HPLC), powder
Assay
≥95% (HPLC)
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
InChI key
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Gene Information
mouse ... Cckbr(12426)
rat ... Cckar(24889) , Cckbr(25706)
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Amino Acid Sequence
Boc-Bal-Trp-Met-Asp-Phe-NH2
General description
Research area: Immunology & cytokines
Application
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]
Biochem/physiol Actions
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]
antibody
inhibitor
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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A Imdahl et al.
The Journal of surgical research, 86(1), 108-115 (1999-08-24)
To clarify the impact of the classic gastrin/CCK-B receptor on the growth of benign and malignant colonic cells, two permanent cell lines expressing this receptor have been established. The conditionally immortalized nonmalignant colonic cell line YAMC and the colonic carcinoma
K McManus et al.
Journal of affective disorders, 66(2-3), 273-279 (2001-10-02)
Panic disorder (PD) symptomatology has been reported to be altered by hormonal events or treatments which affect estrogen levels. Coryell et al. [Arch. Gen. Psychiatry, 39 (1982) 701-703; Am. J. Psychiatry, 143 (1986) 508-510] have suggested that the increased cardiovascular
Consistency of immigrant suicide rates in Austria with country-of-birth suicide rates: A role for genetic risk factors for suicide?
Voracek M, et al.
Psychiatry Research, 170(2-3), 286-289 (2009)
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich J C, et al.
Frontiers in Behavioral Neuroscience, 6(2-3), 16-16 (2012)
L Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(4), 1130-1133 (1991-02-15)
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was
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How can Pentagastrin, Product B1636, solutions be stored?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the shelf-life of Pentagastrin, Product B1636?
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This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.
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What is Pentagastrin, Product B1636, soluble in?
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Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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