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23240

Sigma-Aldrich

4-Nitrophenyl chloroformate

purum, ≥97.0% (AT)

Synonym(s):

Chloroformic acid 4-nitrophenyl ester

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About This Item

Linear Formula:
ClCO2C6H4NO2
CAS Number:
7693-46-1
Molecular Weight:
201.56
Beilstein:
518127
EC Number:
231-706-9
MDL number:
MFCD00007321
UNSPSC Code:
12352101
PubChem Substance ID:
329752399

grade

purum

Assay

≥97.0% (AT)

bp

159-162 °C/19 mmHg (lit.)

mp

76-82 °C
77-79 °C (lit.)

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(OC(Cl)=O)cc1

InChI

1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H

InChI key

NXLNNXIXOYSCMB-UHFFFAOYSA-N

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Other Notes

Reagent for the synthesis of mixed, activated carbonates and thiocarbonates, activated urethanes, and other compounds[1]

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

>230.0 °F

Flash Point(C)

> 110 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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In this study, a type of multifunctional mixed micelles were prepared by a novel biodegradable amphiphilic polymer (MPEG-SS-2SA) and a multidrug resistance (MDR) reversal agent (d-α-tocopheryl polyethylene glycol succinate, TPGS). The mixed micelles could achieve rapid intracellular drug release and
D. Phillips et al.
Tetrahedron Letters, 31, 3291-3291 (1990)
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Journal of orthopaedic translation, 21, 57-65 (2020-02-27)
The survival rate of osteosarcoma therapy still lags behind overall cancer therapies due to the intrinsic or acquired drug resistance. Developing novel drug delivery systems that may overcome drug resistance would greatly facilitate osteosarcoma therapy. Poly(ethylene glycol) (PEG)-sheddable reduction-sensitive polyurethane
Jingjing Pan et al.
ACS applied materials & interfaces, 6(16), 14391-14398 (2014-07-18)
In this work, a novel gene delivery strategy was proposed based on silicon nanowire arrays modified with high-molecular-weight 25 kDa branched polyethylenimine (SN-PEI). Both the plasmid DNA (pDNA) binding capacity and the in vitro gene transfection efficiency of silicon nanowire
Feng Ren et al.
Chemical & pharmaceutical bulletin, 62(9), 898-905 (2014-09-02)
A series of novel benzyloxyurea derivatives was designed, synthesized by substituting different benzyls or phenyls on N,N'-positions of the hydroxyurea (HU). These target compounds were evaluated for their anticancer activity in vitro against human leukemia cell line K562 and murine
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