5.08514
Psalmotoxin-1
Synonym(s):
Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
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About This Item
Empirical Formula (Hill Notation):
C200H312N62O57S6
CAS Number:
Molecular Weight:
4689.39
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥94% (HPLC)
Quality Level
form
semisolid
viscous liquid
potency
0.9 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
colorless
storage temp.
−20°C
General description
A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
Biochem/physiol Actions
Primary Target
ASIC1a
ASIC1a
Warning
Toxicity: Standard Handling (A)
Sequence
EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
Other Notes
Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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