A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target Osteoclast-mediated bone resorption
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
Warning
Toxicity: Standard Handling (A)
Other Notes
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255. Virtanen, S.S., et al. 2002. Cancer Res.62, 2708. Smith, R., et al. 1971. Lancet1, 945. Fleisch, H., et al. 1969. Nature223, 211.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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