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208900

Sigma-Aldrich

Calpastatin, Human, Recombinant, Domain I

Domain I of human calpastatin.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

aqueous buffer: 1 mg/mL
water: 1 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

An endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca2+-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.
Domain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.

Biochem/physiol Actions

50 nM completely inhibits the activity of 7.5 µg/ml calpain I
Cell permeable: no
Primary Target
calpain-1
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Analysis Note

homogeneous by SDS-PAGE

Other Notes

Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
Asada, K., et al. 1989. J. Enzyme Inhib.3, 49.

Legal Information

Not available for sale in Japan.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Philippe M Duquette et al.
Journal of neurochemistry, 152(3), 315-332 (2019-07-26)
During development, neurons extend axons toward their appropriate synaptic targets to establish functional neuronal connections. The growth cone, a highly motile structure at the tip of the axon, is capable of recognizing extracellular guidance cues and translating them into directed

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