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biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... HDAC3(8841)
Specificity
HDAC3
Immunogen
peptide corresponding to amino acids 411-428 of human HDAC3 (NEFYDGDHDNDKESDVEI)
Application
Anti-HDAC3 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC3 also known as histone deacetylase 3 & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Quality
routinely evaluated by immunoblot on a HeLa RIPA cell lysate
Target description
49kDa
Physical form
Format: Purified
Protein A chromatography
of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression
Li, J., et al
Genes & Development, 16, 687-692 (2002)
Y Zeng et al.
The Journal of biological chemistry, 273(44), 28921-28930 (1998-10-24)
Histone deacetylase-2 (HDAC2) is a component of a complex that mediates transcriptional repression in mammalian cells. A mouse HDAC2 cDNA was used to identify several recombinant clones containing the entire mouse HDAC2 gene. The mouse HDAC2 gene spans over 36
Histone acetylation and transcriptional regulatory mechanisms.
Struhl, K
Genes & Development, 12, 599-606 (1998)
K Nakade et al.
Cell death and differentiation, 14(8), 1398-1405 (2007-04-28)
Among the events that control cellular differentiation, the acetylation of histones plays a critical role in the regulation of transcription and the modification of chromatin. Jun dimerization protein 2 (JDP2), a member of the AP-1 family, is an inhibitor of
Histone deacetylase 3 is required for maintenance of bone mass during aging.
McGee-Lawrence, ME; Bradley, EW; Dudakovic, A; Carlson, SW; Ryan, ZC; Kumar, R; Dadsetan et al.
Bone null
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