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855776C

Avanti

19:0 Lyso PC

Avanti Research™ - A Croda Brand 855776C

Synonym(s):

1-nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C27H56NO7P
CAS Number:
108273-88-7
Molecular Weight:
537.71
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (855776C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 855776C

concentration

10 mg/mL (855776C-25mg)

shipped in

dry ice

storage temp.

−20°C

General description

Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid secreted on pathological response. It has a choline group at its polar head.

Application

19:0 Lyso PC has been used for the quantification of lysophosphatidylcholine (LPC) in microsomes by mass spectrometry. It has also been used for plasma lipidome analysis of cows.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) modifies various biological functions in different cell-types, like endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells. It is associated with atherosclerosis and inflammatory diseases. LPC stimulates many second messengers including, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.

Packaging

5 mL Clear Glass Sealed Ampule (855776C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Altered plasma lipidome profile of dairy cows with fatty liver disease
Gerspach C, et al.
Research in Veterinary Science, 110, 47-59 (2017)
Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature
Choudhary V, et al.
Current Biology, 28(6), 915-926 (2018)
Ruichuan Yin et al.
Nature protocols, 14(12), 3445-3470 (2019-11-15)
Mass spectrometry imaging (MSI) enables label-free spatial mapping of hundreds of biomolecules in tissue sections. This capability provides valuable information on tissue heterogeneity that is difficult to obtain using population-averaged assays. Despite substantial developments in both instrumentation and methodology, MSI
Sidra Iqbal et al.
Plant physiology and biochemistry : PPB, 147, 101-112 (2019-12-20)
Plant phospholipase A (PLA) and C (PLC) families are least explored in terms of structure, diversity and their roles in membrane lipid remodeling under stress conditions. In this study, we performed gene family analysis, determined gene expression in different tissues
Dumindika A Siriwardane et al.
International journal of pharmaceutics, 578, 119077-119077 (2020-01-29)
Identification and quantification of excipient related degradation products in the liposomal formulation is important, as they may impact the safety and efficacy of the drug. Phospholipids are one of the major excipients in liposome drugs composing the lipid bilayer, and
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