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410616

Sigma-Aldrich

4-Benzyloxy-2(1H)-pyridone

99%

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About This Item

Empirical Formula (Hill Notation):
C12H11NO2
CAS Number:
53937-02-3
Molecular Weight:
201.22
MDL number:
MFCD00191783
UNSPSC Code:
12352100
PubChem Substance ID:
24865539
NACRES:
NA.22

Assay

99%

form

solid

mp

201-203 °C (lit.)

SMILES string

O=C1NC=CC(OCc2ccccc2)=C1

InChI

1S/C12H11NO2/c14-12-8-11(6-7-13-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,13,14)

InChI key

DOVNUEPFPBWTSV-UHFFFAOYSA-N

General description

N-alkylation of 4-benzyloxy-2(1H)-pyridone with the corresponding benzyl halides has been reported.

Application

4-Benzyloxy-2(1H)-pyridone may be used for the synthesis of novel 2-pyridone derivatives. It may be used for the alkylation of the pyridine nitrogen under mild and anhydrous conditions, via reaction with n-Bu4I and KOBu-t.†

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBR0146V
MKBJ9132V
MKBJ9621V
MKBJ9131V
MKBF5048V

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Tetrahedron Letters, 46, 7917-7917 (2005)
Suresh K Tipparaju et al.
Bioorganic & medicinal chemistry letters, 18(12), 3565-3569 (2008-05-24)
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of

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