SRP6007
NT-3 from mouse
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Synonym(s):
HDNF, NGF-2, NT-3, Nerve growth factor-2, Neurotrophic factor
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
mouse
recombinant
expressed in E. coli
Assay
≥97% (HPLC)
≥97% (SDS-PAGE)
form
lyophilized
mol wt
13.6 kDa
packaging
pkg of 10 μg
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... NTF3(18205)
General description
NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Application
NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples.
Biochem/physiol Actions
Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis.
Physical form
Sterile filtered and lyophilized powder
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
Fari?as I et al
Nature, 369(6482), 658-661 (1994)
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Ernfors P et al
Neuron, 14(6), 1153-1164 (1995)
Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.
Yoshida M et al
The Journal of Neuroscience, 31(35), 12663-12673 (2011)
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA et al
Journal of Neuroscience Methods, 282, 34-42 (2017)
Shyan-Yuan Kao et al.
Bone, 145, 115837-115837 (2021-01-02)
The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG
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