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SAB3500044

Sigma-Aldrich

Anti-AP2M1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AP-2 mu-1, Anti-AP50, Anti-Adaptor-related protein complex 2 mu 1, Anti-CLAPM1, Anti-u2

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

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This Item
WH0001175M1AV53577SAB3500448
biological source

chicken

biological source

mouse

biological source

rabbit

biological source

chicken

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

species reactivity

human, mouse, rat

species reactivity

human

species reactivity

human, dog, rat, mouse, horse, bovine, rabbit, guinea pig

species reactivity

mouse, rat, human

UniProt accession no.

Q96CW1

UniProt accession no.

P53680

UniProt accession no.

P63010

UniProt accession no.

A9UGY9

Immunogen

AP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500044.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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