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Key Documents

P9764

Sigma-Aldrich

Polydeoxyadenylic acid • Polythymidylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly(dA) • Poly(dT)

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About This Item

CAS Number:
86834-22-2
MDL number:
MFCD00131963
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O6P.C10H15N2O8P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19;1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19);3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)

InChI key

KKVQVIFXABFJCS-UHFFFAOYSA-N

Application

Polydeoxyadenylic acid • Polythymidylic acid (Poly(dA) • Poly(dT)) is a double-stranded homopolymer use as a DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Thomas et al.
Journal of biomolecular structure & dynamics, 18(6), 858-871 (2001-07-11)
The binding of three analogues of the minor-groove binding antiviral antibiotic distamycin (Dst) with double-stranded (ds)-DNA were monitored using ds-DNA melting temperature (Tm) measurements, ethidium bromide (EtBr) displacement assay, footprinting analysis and induced circular dichroism (ICD). These compounds contained 3-5
Hongjuan Xi et al.
Biochemistry, 50(42), 9088-9113 (2011-08-26)
Recognition of nucleic acids is important for our understanding of nucleic acid structure as well as for our understanding of nucleic acid-protein interactions. In addition to the direct readout mechanisms of nucleic acids such as H-bonding, shape recognition of nucleic
M A Semenov et al.
Biofizika, 39(4), 628-636 (1994-07-01)
IR-spectrometry and thermopiezogravimetry are used to study the structure formation and the water environment of the double-helix Na-poly(dA)-poly(dT) complex in films in the 0-100% interval of the relative humidity (RH). It has been found that three different structures of the
Marta Airoldi et al.
Biopolymers, 75(2), 118-127 (2004-09-10)
CD and uv absorption data showed that high molecular weight poly(dA-dT) . poly(dA-dT), at 298 K, undergoes an acid-induced transition from B-double helix to random coil in NaCl solutions of different concentrations, ranging from 0.005 to 0.600M. Similarly, titration of
K H Yoo et al.
Physical review letters, 87(19), 198102-198102 (2001-11-03)
We report direct measurements of electrical transport through poly(dA)-poly(dT) and poly(dG)-poly(dC) DNA molecules containing identical base pairs. The observed experimental results suggest that electrical transport through DNA molecules occurs by polaron hopping. We have also investigated the effect of gate
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