P5976
Anti-Platelet-Derived Growth Factor-BB antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-PDGF-BB
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About This Item
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PDGFB(5155)
General description
Platelet-Derived Growth Factor-BB (PDGF-BB) is a cystine-linked homodimer that belongs to PDGF growth factor family and is expressed mainly by vascular endothelium, megakaryocytes and Leydig cells. It has key roles in regulating neurogenesis, producing proinflammatory cytokines by orbital fibroblasts in Graves′ Ophthalmopathy, cell proliferation, development, angiogenesis and cell survival. Anti-Platelet-Derived Growth Factor-BB antibody can be used for neutralizing the biological activity of recombinant human PDGF-BB, recombinant human-AB, natural human PDGF, rat PDGF-BB, and porcine PDGF-BB. It can also neutralize recombinant human PDGF-AA at 50-100 fold high IgG concentration. Goat Anti-Platelet-Derived Growth Factor-BB antibody reacts specifically with human PDGF-BB. The product has also shown less than 10% cross-reactivity for recombinant human PDGF-AA.
Immunogen
Recombinant human PDGF-BB expressed in Escherichia coli.
Application
Anti-Platelet-Derived Growth Factor-BB antibody can be used in immunoblotting and ELISA.
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline pH 7.4 with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Leendert van Steensel et al.
Investigative ophthalmology & visual science, 51(2), 1002-1007 (2009-10-03)
Graves' ophthalmopathy (GO) is characterized by the infiltration of immune cells into the orbit, a process in which cytokines play a central role. Orbital fibroblasts are potent producers of cytokines on different stimuli. Recently, the authors showed increased expression of
Renée V Hoch et al.
Development (Cambridge, England), 130(20), 4769-4784 (2003-09-04)
Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses to platelet-derived growth factors (PDGFs) during animal development. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a
Honghong Yao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(29), 9835-9847 (2012-07-21)
Platelet-derived growth factor-BB (PDGF-BB) has been reported to provide tropic support for neurons in the CNS. However, whether PDGF-BB regulates neurogenesis, especially in the context of HIV-associated neurological disorder and drug abuse, remains essentially unknown. In this study, we demonstrate
Johanna Andrae et al.
Genes & development, 22(10), 1276-1312 (2008-05-17)
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in
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