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D-Lactic Dehydrogenase from Lactobacillus leichmannii

Name: <SC>D</SC>-Lactic Dehydrogenase from Lactobacillus leichmannii
Brand: SIGMA

ammonium sulfate suspension, ≥250 units/mg protein (biuret)

Synonym(s):

Lactate, (R)-Lactate:NAD⁺ oxidoreductase, D−LDH

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About This Item

CAS Number:

9028-36-8

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

1.1.1.28 (BRENDA, IUBMB)

MDL number:

MFCD00130907

Specific activity:

≥250 units/mg protein (biuret)

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Properties

form

ammonium sulfate suspension

Quality Segment

200

specific activity

≥250 units/mg protein (biuret)

foreign activity

Malic dehydrogenase <0.5% of base activity

storage temp.

2-8°C

Description

General description

Research area: Cell Signalling D-lactate dehydrogenase belongs to the D-isomer-specific 2-hydroxyacid dehydrogenase family. Lactate dehydrogenase (LD) is a tetramer consisting of two (H and M) subunits. It has five isozymes (LD1 to LD5) and this composition varies in different tissues. LD1 is abundant in the kidney, heart, and erythrocytes. LD5 is found in the liver and skeletal muscles. LD is a ubiquitous molecule found in plants, yeast, mammals, and microorganisms and is a member of the oxidoreductase family.

Biochem/physiol Actions

Lactic dehydrogenase (LDH)plays an important role in the glycolytic pathway where it converts pyruvate tolactate by using NAD⁺ as a co-factor. It is considered animportant molecule that can be used in cancer therapy as it acts as aglycolytic inhibitor. Inhibition of LDH is associated with blocking of aerobicglycolysis in tumour cells.

Physical form

Suspension in 3.2 M (NH₄)₂SO₄, pH 6.0

Other Notes

One unit will reduce 1.0 μmole of pyruvate to D-lactate per min at pH 7.0 at 25 °C.

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This Item	L2625	A7189	59747
Sigma-Aldrich L2011 D-Lactic Dehydrogenase from Lactobacillus leichmannii	Sigma-Aldrich L2625 L-Lactic Dehydrogenase from bovine heart	Sigma-Aldrich A7189 L-Alanine Dehydrogenase from Bacillus subtilis	Sigma-Aldrich 59747 Lactic Dehydrogenase, recombinant from E. coli
description ammonium sulfate suspension, ≥250 units/mg protein (biuret)	description Type III, ammonium sulfate suspension, ≥500 units/mg protein	description ammonium sulfate suspension, ≥20 units/mg protein (Lowry)	description ≥90 U/mg
specific activity ≥250 units/mg protein (biuret)	specific activity ≥500 units/mg protein	specific activity ≥20 units/mg protein (Lowry)	specific activity ≥90 U/mg
form ammonium sulfate suspension	form ammonium sulfate suspension	form ammonium sulfate suspension	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
foreign activity Malic dehydrogenase <0.5% of base activity	foreign activity pyruvate kinase ≤0.03%	foreign activity -	foreign activity -

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Storage Class

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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