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GW21442

Sigma-Aldrich

Anti-DPP4 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD26, Anti-Dipeptidyl peptidase 4

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

manufacturer/tradename

Genway 15-288-21442

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DPP4(1803)

General description

Dipeptidyl peptidase-4 (DPP4) is a serine type protease is also known as CD26 or adenosine deaminase binding protein. It is expressed in the plasma membranes of T cells and activated natural killer or B cells. Its expressions also have been found on a number of endothelial and differentiated epithelial cells.

Immunogen

Immunogen Sequence: GI # 4503367, sequence 547-610
Recombinant dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

Application

Anti-DPP4 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Dipeptidyl peptidase-4 (DPP4) is a protein encoded by the DPP4 gene in humans. The T cell activation molecule DPP4 is associated with a 43kDa protein. It is associated with multiple sclerosis (MS) pathophysiology. DPP4 interacts on the T cell surface along with adenosine deaminase (ADA). Mutation in DPP4 causes an X-linked Simpson-Golabi-Behmel syndrome.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C Durinx et al.
European journal of biochemistry, 267(17), 5608-5613 (2000-08-22)
Dipeptidyl peptidase IV (DPPIV, EC 3.4.14.5) is a serine type protease with an important modulatory activity on a number of chemokines, neuropeptides and peptide hormones. It is also known as CD26 or adenosine deaminase (ADA; EC 3.5.4.4) binding protein. DPPIV
J Kameoka et al.
Science (New York, N.Y.), 261(5120), 466-469 (1993-07-23)
CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T
Jamshid Davoodi et al.
Proteomics, 7(13), 2300-2310 (2007-06-06)
Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked condition shown to be the result of deletions of the glypican-3 (GPC3) gene. GPC3 is a proteoglycan localized to the cell membrane via a glycosylphosphatidyl-inositol (GPI) anchor. To further elucidate the GPC3 function(s), we
Marta Tejera-Alhambra et al.
Clinical immunology (Orlando, Fla.), 150(2), 170-183 (2014-01-15)
Multiple sclerosis (MS) is a prototypic Th1/Th17 chronic autoimmune disease of the central nervous system. Dipeptidyl peptidase 4 (DPP4 or CD26) is a multifunctional molecule involved in autoimmune diseases' pathophysiology. We sought to integrate disparate pieces of data and analyze

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