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Key Documents

E6527

Sigma-Aldrich

Elastin, soluble from bovine neck ligament

salt-free, lyophilized powder

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About This Item

CAS Number:
9007-58-3
EC Number:
232-701-4
MDL number:
MFCD02687372
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

bovine neck ligament

Quality Level

100

form

salt-free, lyophilized powder

technique(s)

UV/Vis spectroscopy: suitable

UniProt accession no.

P04985

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

cow ... ELN(280781)

General description

Water-soluble powder prepared by method of Partrige, et al.

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.

Biochem/physiol Actions

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

Caution

Forms coacervate at pH 5.0 and 37 °C

Suitability

Suitable for determination of elastolytic activity as described by Keller and Mandi.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felix Cleemann et al.
Analytical chemistry, 80(11), 4170-4174 (2008-04-25)
A novel fluorescence polarization assay based on the natural fluorophore epicocconone has been developed. This assay allows the rapid and accurate determination of enzyme kinetic parameters as well as inhibition constants through the measurement of fluorescence anisotropy on the actual
A Panagopoulou et al.
Biochimica et biophysica acta, 1834(6), 977-988 (2013-03-27)
Dynamics of uncrystallized water and protein was studied in hydrated pellets of the fibrous protein elastin in a wide hydration range (0 to 23wt.%), by differential scanning calorimetry (DSC), thermally stimulated depolarization current technique (TSDC) and dielectric relaxation spectroscopy (DRS).
Stefanie Michael et al.
PloS one, 8(3), e57741-e57741 (2013-03-08)
Tissue engineering plays an important role in the production of skin equivalents for the therapy of chronic and especially burn wounds. Actually, there exists no (cellularized) skin equivalent which might be able to satisfactorily mimic native skin. Here, we utilized
Maria Delio et al.
American journal of medical genetics. Part A, 161A(3), 527-533 (2013-02-13)
Haploinsufficiency of the elastin gene (ELN) on 7q11.23 is responsible for supravalvular aortic stenosis (SVAS) and other arteriopathies in patients with Williams-Beuren syndrome (WBS). These defects occur with variable penetrance and expressivity, but the basis of this is unknown. To
Naoko Morisaki et al.
PloS one, 8(2), e55947-e55947 (2013-02-19)
In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively) called the hair cycle. Various biological factors have been reported to regulate or to synchronize with the hair cycle. Some
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