The recommended long-term storage temperature for this product is at 2 - 8 °C. However, this product ships at ambient temperature and is stable for short periods without refrigeration.
D1756
Dexamethasone
Dexamethasone
≥98% (HPLC), powder, NOS induction inhibitor
Synonym(s):
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
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About This Item
Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
Molecular Weight:
392.46
Beilstein:
2066651
EC Number:
MDL number:
UNSPSC Code:
51422306
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Dexamethasone, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
off-white
mp
262-264 °C (lit.)
solubility
methanol: 25 mg/mL
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.
2-8°C
SMILES string
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key
UREBDLICKHMUKA-CXSFZGCWSA-N
Gene Information
human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)
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General description
Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways,[1] some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.
Application
Biochem/physiol Actions
Dexamethasone is known to be effective against relapsed multiple myeloma.[5] It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.[6]
Glucocorticoid anti-inflammatory agent
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.
Reconstitution
Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Articles
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is it ok to store the powder at room temperature?
1 answer-
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We plan dissolve it in DMSO and use for experiment (Inject to Mice via IM way), so Which is the appropriate concentration of DMSO?
1 answer-
Dexamethasone is soluble in 100% DMSO at a concentration of 25 mg/mL.
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Is it okay to freeze and store the solution mixed with a vehicle such as 2-hydroxypropyl-β-cyclodextrin for a long time, and melt and freeze repeatedly?
1 answer-
Solutions prepared in 2-hydroxypropyl-β-cyclodextrin may be stored in aliquots at -20ºC. Avoid repeated freeze/thaw cycles. Note that product D2915 is a prepared powder mixture of Dexamethason and 2-hydroxypropyl-β-cyclodextrin. This product is soluble at 25 mg/ml in water. Please see the link below to review additional water-soluble product options:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdfPlease see the following link to review (2-Hydroxypropyl)-β-cyclodextrin product options:
https://www.sigmaaldrich.com/substance/2hydroxypropylbcyclodextrin12345128446355Helpful?
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Please can someone confirm if this is also soluble in DMSO? I have seen other people dissolve dexamethasone like this, but with a different brand
1 answer-
Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or Ethanol.
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What is Product D1756, Dexamethasone, soluble in?
1 answer-
Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane, and slightly soluble in chloroform. Sigma routinely tests the solubility at 50 mg/mL in ethanol with heat, yielding a clear, colorless to faint yellow solution. However, dexamethasone will precipitate out of solution as the temperature returns to room temperature. At 25 mg/mL in methanol or ethanol, a clear colorless solution is obtained without heating. The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability of Product D1756, Dexamethasone?
1 answer-
Aqueous solutions of dexamethasone are stable for at least 30 days at 4°C. A stock solution at a concentration of 1mg/mL in absolute ethanol can be diluted 1:50 with sterile media and stored frozen as working aliquots.
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Is Product D1756, Dexamethasone, suitable for cell culture?
1 answer-
This product has not been tested for cell culture. Please consider either Product No. D8893 or D4902, both of which are cell culture tested.
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