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00750

Sigma-Aldrich

Acetone oxime

purum, ≥98.0% (GC)

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About This Item

Linear Formula:
(CH3)2C=NOH
CAS Number:
Molecular Weight:
73.09
Beilstein:
1560146
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.02

grade

purum

Quality Level

Assay

≥98.0% (GC)

bp

135 °C (lit.)

mp

59-61 °C
60-63 °C (lit.)

density

0.901 g/mL at 25 °C (lit.)

SMILES string

C\C(C)=N/O

InChI

1S/C3H7NO/c1-3(2)4-5/h5H,1-2H3

InChI key

PXAJQJMDEXJWFB-UHFFFAOYSA-N

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Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Flam. Sol. 2 - Skin Sens. 1B

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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R S Sodum et al.
Chemical research in toxicology, 10(12), 1420-1426 (1998-01-23)
Previously, the secondary nitroalkane 2-nitropropane, a strong hepatocarcinogen in rats, had been shown to induce the formation of 8-aminoguanine in both DNA and RNA of rat liver through a sulfotransferase-mediated pathway. This pathway was postulated to convert the carcinogen into
C Kohl et al.
Carcinogenesis, 13(7), 1091-1094 (1992-07-01)
The hepatocarcinogenicity of acetoxime has been tentatively linked with its metabolic oxidation to the potent genotoxicant and carcinogen propane 2-nitronate (P2-N). In order to test the hypothesis that acetoxime is metabolized to P2-N, the oxime (20 mM) was incubated with
M Rysková et al.
Folia biologica, 43(1), 19-24 (1997-01-01)
The genotoxic effects of N-nitroso-N-methylurea (MNU) and acetone oxime (ACOX) were tested in the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. We have performed the same assay on transgenic flies expressing the human gene encoding a glutathione S-transferase
Stefanie Zorbas-Seifried et al.
Molecular pharmacology, 71(1), 357-365 (2006-10-20)
The presence of cis-configured exchangeable ligands has long been considered a prerequisite for antitumor activity of platinum complexes, but over the past few years, several examples violating this structure-activity relationship have been recognized. We report here on studies with the
N S Hussain et al.
Carcinogenesis, 11(6), 1013-1016 (1990-06-01)
Acetoxime (ACO) and 2-nitropropane (2-NP), both industrially important chemicals and known hepatocarcinogens in rats, induced increased levels of 8-hydroxy-guanine in liver DNA and RNA of male Sprague-Dawley and F344 rats after either oral or i.p. administration. Both compounds also produced

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