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MABD45

Sigma-Aldrich

Anti-DDPIV/CD26 Antibody, clone 9F1.2

clone 9F1.2, from mouse

Synonym(s):

Dipeptidyl peptidase 4, ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, CD26, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptida

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9F1.2, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2aκ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DPP4(1803)

Related Categories

General description

Dipeptidyl peptidase 4 (EC 3.4.14.5; UniProt P27487; also known as ADABP, ADCP-2, Adenosine deaminase complexing protein 2, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, Dipeptidyl peptidase 4, Dipeptidylpeptidase IV, TP103) is encoded by the DPP4 (also known as CD26, ADCP2) gene (Gene ID 1803) in human. DPPIV is a homodimeric serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. It is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes. Also, DPPIV acts as a functional receptor for the newly discovered Middle East respiratory syndrome (MERS) coronavirus.

Specificity

Reacts with both membrane-bound (MDPP) and soluble (SDPP) forms.

Immunogen

Epitope: extracellular domain
GST-tagged recombinant protein corresponding to the extracellular domain of human DDPIV/CD26.

Application

Research Category
Stem Cell Research
Research Sub Category
Endothelial Stem Cells
This Anti-DDPIV/CD26 Antibody, clone 9F1.2 is validated for use in Western Blotting for the detection of DDPIV/CD26.

Quality

Evaluated by Western Blotting in PC3 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected DDPIV/CD26 in 10 µg of PC3 cell lysate.

Target description

~100 kDa observed. Due to glycosylation, target band appears larger than the calculated molecular weight of 88.3 (MDPP) & 84.4 (SDPP) kDa Uncharacterized band(s) may appear in some lysates.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiaoliang Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 205(6), 1653-1663 (2020-08-17)
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide evidence for a potential role of serine

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