475886
NG-Monomethyl-L-arginine, Monoacetate Salt
Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.
Synonym(s):
NG-Monomethyl-L-arginine, Monoacetate Salt, N ω-Me-L-Arg, N G-Me-L-Arg, AcOH, L-NMMA, Nω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA
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About This Item
Empirical Formula (Hill Notation):
C7H16N4O2 · xC2H4O2
CAS Number:
Molecular Weight:
188.23 (free base basis)
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥99% (HPLC)
≥99% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
methanol: soluble
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
InChI key
IKPNWIGTWUZCKM-JEDNCBNOSA-N
General description
Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS; Ki = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
L-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (Ki = 650 nM for nNOS; Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
eNOS
eNOS
Product does not compete with ATP.
Reversible: no
Target Ki: 700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.
Other Notes
Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys.320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun.158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA85, 8664.
Hibbs, J.B., et al. 1987. Science237, 473.
Palmer, R.M.J., et al. 1987. Nature327, 524.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun.158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA85, 8664.
Hibbs, J.B., et al. 1987. Science237, 473.
Palmer, R.M.J., et al. 1987. Nature327, 524.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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