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415057

Sigma-Aldrich

Magnesium stearate

technical grade

Synonym(s):

Stearic acid magnesium salt

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About This Item

Linear Formula:
[CH3(CH2)16CO2]2Mg
CAS Number:
557-04-0
Molecular Weight:
591.24
Beilstein:
3919702
EC Number:
209-150-3
MDL number:
MFCD00036391
UNSPSC Code:
12352100
PubChem Substance ID:
24865972
NACRES:
NA.22
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grade

technical grade

form

powder

composition

palmitate salt, 25%
stearate salt, 65%

mp

200 °C (lit.)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

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General description

Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared.[1] The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.[2] Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution.[3] Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.[4]

[4]Magnesium stearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.[5]

Application

Magnesium stearate may be used as excipient in the formulations of diclofenac sodium tablets.[6] It may be used for the preparation of tramadol HCl matrix tablets.[7]

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB2373
STBL3173
STBK5280
STBK4159
STBJ9826

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Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species.
Sharpe SA, et al.
Structural Chemistry, 8(1), 73-84 (1997)
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
Hobbs CA, et al.
Toxicology Reports, 4, 554-559 (2017)
Louis St-Onge et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 8(2), 272-288 (2005-08-30)
Laser-induced breakdown spectroscopy (LIBS) was evaluated for its potential as a process analytical tool for the rapid determination of magnesium stearate (MgSt) distribution within and between tablets as well as between batches in a typical manufacturing run, and for the
Jaleh Varshosaz et al.
AAPS PharmSciTech, 7(1), E24-E24 (2006-04-06)
The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively
Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets.
Kikuta J-I and Kitamori N.
Drug Development and Industrial Pharmacy, 20(3), 343-355 (1994)
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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