SRP6508
Haptoglobin (Phenotype 2-2) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Hp 2-2
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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General description
Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.
Application
Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.
Biochem/physiol Actions
Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.
Physical form
Lyophilized as a salt-free solid.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer
Guimin G, et al.
PLoS Genetics (2017)
Haptoglobin 2-2 Genotype is Not Associated With Cardiovascular Risk in Subjects With Elevated Glycohemoglobin?Results From the Bruneck Study
Raimund P, et al.
Journal of the American Heart Association (2014)
Haptoglobin polymorphisms and iron homeostasis in health and in disease
Van H, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 35-42 (2004)
Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage
Chaichana K, et al.
Stroke, 38(12), 3266-3271 (2007)
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Rinkoo D, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 13(5), 373?376-373?376 (2016)
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